Bombesinother name Bombesin-like peptides are a diverse group of neuropeptides that play significant roles in physiological processes, including appetite regulation, stress response, and cell growth.Bombesin-like peptides can function as autocrine growth ... Originally discovered in amphibian skin, these peptides and their mammalian counterparts, such as gastrin-releasing peptide (GRP) and neuromedin B (NMB), are now recognized for their widespread presence and multifaceted functions in vertebrates18F-Labeled Bombesin Analog for Specific and Effective .... The study of bombesin-like peptides is crucial for understanding their involvement in both normal bodily functions and various pathological conditions, particularly in cancer.
The journey of bombesin-like peptides began with the isolation of bombesin itself from the skin of the frog *Bombina bombina*作者：X Zhou·2017·被引用次数：18—Bombesin-like peptides, like many other active peptides, are synthesized as larger protein precursors that are enzymatically converted to their mature forms.. Subsequent research revealed that mammals possess related peptides that share sequence homology and biological effects with amphibian bombesinBombesin-like peptides – Knowledge and References. The primary mammalian equivalents are gastrin-releasing peptide (GRP) and neuromedin B (NMB). These peptides, along with others, form distinct subfamilies, including the GRP, NMB, and BRP families, highlighting their evolutionary diversity.
Bombesin-like peptides are implicated in a wide array of physiological functions. One of their well-documented roles is the regulation of food intake; they can inhibit appetite when administered peripherally or centrally, acting on satiety mechanisms.18F-Labeled Bombesin Analog for Specific and Effective ... Beyond appetite control, these peptides are involved in mediating stress responses, influencing normal lung development, and modulating inflammation. Their actions are often mediated through specific receptors, such as the BB1 and BB2 receptors, which are part of the mammalian bombesin receptor system. This system is crucial for regulating energy homeostasis, making it a potential target for pharmacological interventions related to metabolic disordersBombesin‐like Peptides - Walsh - Major Reference Works.
A significant area of research concerning bombesin-like peptides is their role in cell growth and their association with cancer. They have been shown to promote the growth of various cell lines, including those found in carcinomas. In several forms of cancer, such as lung, prostate, breast, and colon cancers, bombesin-like peptides are over-expressed. This overexpression, often acting through an autocrine or paracrine mechanism where cells produce substances that act on themselves or nearby cells, suggests a critical role in tumor development and progression. The gastrin-releasing peptide receptor (GRPr), for instance, is highly overexpressed on prostate cancer cells, making bombesin analogues potential tools for targeted therapies and diagnostic imagingBombesin-like peptides – Knowledge and References.
The diverse functions and implications of bombesin-like peptides have spurred considerable research.作者：H Ohki-Hamazaki·2005·被引用次数：227—Bombesinand two majorbombesin-like peptidein mammals, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been shown to elicit various ... Studies have focused on their biochemical characterization, distribution within the body (e.Bombesin-like peptides – Knowledge and Referencesg., higher concentrations found in the antrum compared to the brain), and their mechanisms of action, including their ability to activate protein kinase C.Bombesin-like Peptides | SpringerLink The development of novel bombesin-like peptides and analogues, such as those designed for GRP-receptor targeting, holds promise for therapeutic applications. These include potential treatments for obesity, stress-related disorders, and various cancers, leveraging their ability to modulate specific cellular pathways and receptorsBombesin-like peptides in mammals. - Abstract.
In conclusion, bombesin-like peptides represent a fascinating and vital class of signaling molecules. From their initial discovery in amphibians to their complex roles in mammalian physiology and pathology, ongoing research continues to uncover their significance in areas ranging from metabolism and stress to cancer biology, offering exciting prospects for future medical advancements.
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