protein-vs-peptide-vs-amino-acid Antibiofilm peptides represent a promising class of molecules designed to combat the persistent challenges posed by bacterial biofilms.作者：A Di Somma·2020·被引用次数：255—Antimicrobialpeptidesare shortpeptidesendowed with a broad range of activity against both Gram-positive and Gram-negative bacteria and are less prone to ... These complex microbial communities, often encased in a protective matrix, are notoriously resistant to conventional antibiotics, leading to chronic infections and treatment failures. Antibiofilm peptides, a subset of antimicrobial peptides (AMPs) or host defense peptides (HDPs), offer a distinct approach by targeting biofilm formation or eradicating established biofilms作者：G Agüero-Chapin·2023·被引用次数：15—Although they have long represented a threat due to their resistance to antibiotics, there arecurrently no approved antibiofilm agents for clinical treatments.. Their broad-spectrum activity and ability to overcome antibiotic resistance make them a critical area of research for developing new therapeutic strategies.
Antibiofilm peptides (ABPs) are short, naturally occurring or synthetically designed peptides that interfere with the development and maintenance of bacterial biofilms作者：GGOS Silveira·2021·被引用次数：48—Antibiofilm peptides (ABPs) represent an exciting class of agents with potent activity against biofilms both in vitro and in vivo.. Unlike traditional antibiotics that primarily focus on killing planktonic (free-swimming) bacteria, ABPs can act at various stages of biofilm formationAntibiofilm Peptides: Relevant Preclinical Animal Infection .... This includes preventing bacteria from attaching to surfaces, disrupting intercellular communication within the biofilm, or degrading the protective extracellular matrix. This multifaceted action is crucial, as biofilm-forming bacteria can exhibit resistance levels 10 to 1000 times higher than their planktonic counterpartsAntibiofilm Peptides: Relevant Preclinical Animal Infection ....
The efficacy of antibiofilm peptides stems from their diverse mechanisms. Many ABPs are cationic and amphipathic, meaning they possess both positive charges and both hydrophobic and hydrophilic regions. This allows them to interact with the negatively charged bacterial cell membranes, leading to membrane disruption and cell death.作者：GGOS Silveira·2021·被引用次数：48—Anti-biofilm peptides are a subset of antimicrobial peptides andrepresent promising broad-spectrum agentsfor the treatment of bacterial ... However, their antibiofilm activity often goes beyond direct killing. Some peptides can interfere with quorum sensing, the system bacteria use to communicate and coordinate their behavior, thus preventing the initiation of biofilm formationComplex Networks Analyses of Antibiofilm Peptides. Others may target specific proteins or enzymes involved in matrix production or biofilm maturation, effectively dismantling the protective structure.
While many antibiofilm peptides are derived from natural sources as part of the innate immune system, significant research is focused on developing synthetic antibiofilm peptides. Synthetic approaches offer greater control over peptide structure, allowing for optimization of activity, stability, and reduced toxicityAntimicrobial peptides as potential anti-biofilm agents .... Recent developments in this field include the design of peptides with enhanced broad-spectrum activity against a wide range of pathogens, including those resistant to multiple antibiotics. Researchers are exploring novel peptide sequences and modifications to create potent and specific agents for therapeutic use.
The potential of antibiofilm peptides as therapeutic agents is substantialAntimicrobial Peptides With Antibiofilm Activity Against .... They offer a novel strategy to treat chronic and recurrent infections that are difficult to manage with current treatments. Their broad-spectrum activity is particularly valuable in situations where the specific pathogen or its resistance profile is unknown作者：C de la Fuente-Núñez·2016·被引用次数：261—We reviewrecent developments in the new field of synthetic antibiofilm peptides, including mechanistic insights, synergistic interactions with available .... Furthermore, their ability to work synergistically with existing antibiotics is being investigated, potentially revitalizing older drugs by making them effective against resistant biofilms.
However, challenges remain. Ensuring the stability and delivery of these peptides in vivo, minimizing potential toxicity to host cells, and scaling up production for clinical use are critical hurdles. Despite these challenges, the ongoing research into the design, mechanisms, and applications of antibiofilm peptides holds great promise for overcoming the significant threat posed by biofilm-related infections.
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