IKVAVpeptide The yigsr peptide, a specific sequence derived from laminin, is a significant molecule in biological research due to its diverse roles in cell adhesion, tissue development, and its potential as a therapeutic agent. This pentapeptide, composed of tyrosine, isoleucine, glycine, serine, and arginine (Tyr-Ile-Gly-Ser-Arg), acts as a key binding site on laminin, a crucial protein in the extracellular matrix作者：SP Massia·1993·被引用次数：297—GYIGSRY promoted cell spreading and stress fiber formationwhen it was covalently immobilized through the amino-terminal Gly residue, used as a spacer arm.. Its ability to modulate cellular behavior has led to extensive investigation into its applications, particularly in areas like wound healing, cancer research, and tissue engineering.
The primary function of the yigsr peptide is its mediation of cell adhesion. As a fragment of laminin, it binds to specific laminin receptors on cell surfaces, facilitating the attachment, migration, and organization of cellsThe laminin-derived peptide YIGSR (Tyr–Ile–Gly–Ser–Arg .... This process is fundamental for normal embryonic development, where cells need to move and assemble into complex tissues. Research indicates that immobilizing yigsr peptide onto biomaterials can effectively promote cellular adhesion, making it a valuable tool for developing biocompatible surfaces for medical implants and tissue scaffolds. For instance, it has been shown to increase endothelial cell adhesion, suggesting its utility in vascular graft development, while also promoting cell spreading and stress fiber formation when covalently immobilized.
One of the most extensively studied areas of yigsr peptide research is its potential as an antitumor agent.VitroGel YIGSR High Concentrationis a tunable, xeno-free (animal origin-free) hydrogel system modified with laminin-derived functional peptide (YIGSR). Studies have demonstrated that this peptide can inhibit tumor growth and metastasis. It achieves this by blocking the cellular binding to laminin, which is crucial for tumor cell invasion of basement membranes and their subsequent spread to other parts of the body.Laminin Pentapeptide YIGSR Specifically, the yigsr peptide has shown inhibitory effects on the metastasis of melanoma and fibrosarcoma cells, and it can reduce the formation of lung colonies in mice injected with melanoma cells. Furthermore, it has been observed to regulate tumor growth by impacting both angiogenesis and direct tumor cell interactions.Laminin Peptide YIGSR Its ability to be delivered via liposomes further enhances its potential for targeted tumor therapy.
Beyond its anti-cancer properties, the yigsr peptide also shows promise in regenerative medicine and wound healing. Research suggests that it can play a role in stimulating collagen synthesis in dermal fibroblasts, a critical process for skin repair and tissue regeneration. Studies have shown that yigsr peptide treatment can ameliorate conditions like lymphedema, protecting epidermal and dermal tissues and enhancing intercellular space organization.作者：SY Boateng·2005·被引用次数：195—We describe a method to adhere thesynthetic peptides RGD (fibronectin) and YIGSR (laminin) onto silicone for culturing primary cardiac cells. Its capacity to promote peripheral nerve regeneration when coated onto collagen fibers further highlights its therapeutic value in tissue repair.
The yigsr peptide is also being integrated into advanced cell culture techniques. Hydrogel systems modified with this peptide, such as VitroGel YIGSR, are used for 3D cell culture, providing a more physiologically relevant environment for studying cell behavior.Enhanced inhibitory effect of polymeric star burst formed ... This allows researchers to better understand cellular interactions and responses in a three-dimensional context. Additionally, emerging research indicates that yigsr peptide can modulate macrophage inflammatory states, influencing the balance between M1 and M2 phenotypes depending on its concentration. This suggests potential applications in managing inflammatory conditions.
The yigsr peptide can be synthesized chemically, allowing for controlled production and modificationLaminin peptide YIGSR induces collagen synthesis in .... Variations such as Laminin Pentapeptide YIGSR-NH2 are commercially available from various suppliers, often with specified purity levels (e.gLaminin Peptide YIGSR-NH2· Currency: · GBP · EUR. £123.00. add to basket. Shipping is calculated in checkout. Product details. Purity: ≥98%. Molecular Weight:.., ≥98%) and molecular weights.New analogues of laminin active fragment YIGSR ... Researchers also explore the synthesis and biological activity of new analogues of the yigsr peptide to enhance its efficacy and specificityYIGSR, a Synthetic Laminin Pentapeptide, Inhibits .... While the core sequence is Tyr-Ile-Gly-Ser-Arg, modifications like amidation (YIGSR-NH2) are common for specific applications or improved stability.
The yigsr peptide is a versatile and potent biomolecule with significant implications across various fields of biological and medical research.作者：A Jha·2024·被引用次数：5—YIGSR can be used as a tool to modulate macrophage inflammatory statewithin M1 and M2 phenotypes depending on the concentration of peptide. Its fundamental role in cell adhesion and tissue development, coupled with its demonstrated ability to inhibit tumor growth and metastasis, and promote tissue regeneration, underscores its therapeutic potential作者：S Itoh·2005·被引用次数：58—Synthetic collagen fibers coated with a syntheticpeptidecontaining theYIGSRsequence of laminin promote peripheral nerve regeneration in vivo .... As research continues to uncover new facets of its activity, from modulating inflammatory responses to enhancing 3D cell culture systems, the yigsr peptide remains a key area of interest for developing novel treatments and advanced biomaterials.
Join the newsletter to receive news, updates, new products and freebies in your inbox.