peptide-natural Peptide nanoparticles represent a sophisticated class of nanomaterials that integrate the unique properties of peptides with the structural advantages of nanoparticles, emerging as powerful tools for a wide array of biomedical applications. These conjugates, often referred to as PNCs (peptide-nanoparticle conjugates), leverage peptides for their specificity, biocompatibility, and ability to self-assemble, while nanoparticles provide a robust scaffold for payload delivery, imaging, and targeted therapeutic action2024年3月29日—Peptides conjugated nanoparticles (NPs) arepromising platforms for biomedical applicationssuch as drug/gene delivery, targeting, sensing, and imaging.. This synergy allows for enhanced drug delivery, precise imaging of disease sites like cancer cells, and the development of novel diagnostic and preventative strategies.Tissue-specific mRNA delivery and prime editing with ...
The core innovation behind peptide nanoparticles lies in the strategic conjugation of peptides to nanoparticle structures. This fusion creates advanced platforms that can overcome limitations of traditional therapeutics.Peptide-Functionalized Lipid Nanoparticles for Targeted ... For instance, peptides can be designed to target specific cell surface receptors, enabling the precise delivery of therapeutic agents or imaging molecules directly to diseased tissues, thereby minimizing off-target effects and improving efficacy. Nanoparticles, in turn, can protect sensitive peptide payloads from degradation in the body, control their release kinetics, and improve their overall bioavailability. This is crucial for peptide-based drugs, which often suffer from poor stability and rapid clearance.作者：C Pigliacelli·2020·被引用次数：59—This feature article summarizes the different methodologies that have been developed to obtainself-assembled peptide–inorganic nanoparticle hybrid...
One of the most significant applications of peptide nanoparticles is in targeted drug and gene deliverySYNTHESIS OF PEPTIDE-BASED NANOPARTICLES VIA .... By functionalizing nanoparticles with targeting peptides, researchers can direct them to specific cellular populations, such as cancer cellsPeptide-Functionalized Lipid Nanoparticles for Targeted .... This targeted approach is fundamental to PNCs enabling targeted delivery of imaging agents to cancer cells, facilitating sensitive detection and diagnosisA Peptide-Nanoparticle System with Improved Efficacy .... Beyond imaging, this targeted delivery mechanism is also being explored for the precise administration of chemotherapeutics, gene-editing tools like mRNA, and other therapeutic molecules.
Furthermore, peptide nanoparticles are at the forefront of theranostic development, a field that combines diagnostics and therapeutics作者：M Herrera-Barrera·2023·被引用次数：212—We have developedpeptide-conjugated LNPs that can enable mRNA delivery to the neural retina, expanding the utility of LNP-mRNA therapies for inherited .... A single peptide nanoparticle system can be engineered to both diagnose a disease (e作者：P Boisguérin·2021·被引用次数：86—In this review, we attempt to cover the most important biophysical and biological aspects ofnon-viral peptide-based nanoparticles(PBNs) for therapeutic ....g., through imaging) and deliver a therapeutic agent to the affected site. This dual functionality streamlines treatment pathways and offers a more personalized approach to medicine. For example, peptide-guided lipid nanoparticles are showing promise in delivering mRNA to specific tissues, opening new avenues for treating genetic disorders.
The ability of peptides to self-assemble into ordered nanostructures is another key characteristic exploited in the creation of peptide nanoparticles. These self-assembling peptide nanoparticles (SAPNs) can form diverse nanostructures, such as micelles, fibers, or vesicles, often with controlled pore sizes, which can encapsulate therapeutic payloads. The process of controlling self-assembly within nanospace for peptide nanoparticle fabrication is a critical area of research, as it allows for precise tuning of nanoparticle size, morphology, and drug-loading capacity.作者：Y Lin·2026·被引用次数：15—Lipid nanoparticles for mRNA delivery and gene editinghave the potential to transform the current therapeutic landscape. This bottom-up approach, often utilizing amino acids and microfluidic systems for synthesis, offers a versatile route to creating custom-designed nanoparticles with specific functional properties.
Despite their immense potential, challenges remain in the widespread clinical translation of peptide nanoparticlesPeptide-based nanomaterials: Self-assembly, properties .... Ensuring the stability and scalability of their synthesis, managing potential immunogenicity, and optimizing their pharmacokinetic profiles are ongoing areas of investigation. However, the continuous advancements in peptide design, nanoparticle engineering, and conjugation strategies suggest a bright future for these versatile platforms作者：CD Spicer·2018·被引用次数：516—Peptide and protein nanoparticle conjugateshave emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, and prevention of .... As research progresses, peptide nanoparticles are poised to transform disease treatment, diagnosis, and prevention, offering innovative solutions for a range of challenging medical conditions.Peptide and protein nanoparticle conjugates: versatile ... Their ability to combine specificity, biocompatibility, and functional payload delivery makes them a cornerstone of next-generation biomedical technologies.
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