DNSP-11 buy The DNSP-11 peptide, also known as Dopamine Neuron Stimulating Peptide-11, is an 11-amino acid synthetic peptide derived from the pro-domain of human Glial Cell Line-Derived Neurotrophic Factor (GDNF). Research indicates that DNSP-11 exhibits significant neurotrophic and neuroprotective properties, particularly towards dopamine neurons. This peptide has demonstrated the ability to support the survival of these critical neurons and offers protection against cell death induced by various damaging agents, making it a subject of considerable interest in neurological research.
DNSP-11 originates from the pro-GDNF domain, a region of the GDNF protein that is processed to yield the mature GDNF.作者：YA Sidorova·2020·被引用次数：24—A predicted endopeptidase cleavage product from the GDNF proregion called DNSP-11, a peptide thatincludes 11 consecutive amino acid residuesfrom the proregion ... Unlike GDNF itself, DNSP-11 is a specific cleavage product, an 11-mer peptide, that retains important bioactivity. Its synthetic nature allows for controlled production and purification, with high purity (≥98% HPLC) being a standard for research-grade material. This precise composition is key to its predictable effects on neural cells.
A primary focus of research into DNSP-11 is its potent neuroprotective activityDNSP-11 is an 11-mer peptidefrom the pro-GDNF domain with neurotrophic and neuroprotective activity toward dopamine neurons. Packaging. 1 mg in glass bottle.. Studies have shown that DNSP-11 can shield dopaminergic neuroblastoma cells from apoptotic cell death, a critical process implicated in neurodegenerative diseases. This protection extends to cell death induced by agents like staurosporine and 6-hydroxydopamine (6-OHDA), a neurotoxin commonly used in animal models to mimic Parkinson's disease. Furthermore, DNSP-11 has been observed to activate neuroprotective signaling pathways, such as the ERK signaling cascade, which plays a vital role in cell survival and function. Beyond protection, DNSP-11 also promotes the survival of fetal mesencephalic neurons, suggesting a broader role in supporting neuronal health and development(A) DNSP-11 (filled) isan 11 amino acid sequence present in the proprotein regionof the 211 amino acid human pre-proGDNF sequence. After cleavage of the pre- ....
The ability to effectively deliver therapeutic agents to the central nervous system (CNS) is a significant challenge in neuroscience.a The predicted enzymatic processing of DNSP-11 in ... DNSP-11 has shown promise with intranasal delivery methodsMethodology and Effects of Repeated Intranasal Delivery of .... Studies indicate that DNSP-11 can be administered intranasally and maintain its neuroactive properties, reaching the CNS and exerting its beneficial effects. This non-invasive delivery route is particularly attractive for potential therapeutic applications, offering a more accessible method compared to direct injection into the brain. The research exploring repeated intranasal delivery of DNSP-11 in animal models of Parkinson's disease further supports its potential as an easily administrable therapeutic agent.
DNSP-11 is primarily utilized as a specialized research peptide for advanced scientific exploration in neurobiology(A) DNSP-11 (filled) is an 11 amino acid sequence present .... Its established effects on dopamine neurons make it a valuable tool for investigating the mechanisms underlying neuroprotection and neurotrophic support. Researchers are exploring its potential in models of Parkinson's disease, where the degeneration of dopamine neurons is a hallmark. While still in the research phase, the consistent demonstration of positive effects in cellular and animal models positions DNSP-11 as a peptide of significant interest for future therapeutic developmentPeptides in Neurology: What Are They, and Can They Really Help Me .... Further studies are ongoing to fully elucidate its mechanisms of action and to assess its efficacy and safety in various neurological contextsDopamine Neuron Stimulating Actions of a GDNF Propeptide.
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