Cocaine- and amphetamine-regulated transcript CART peptides, derived from the Cocaine- and Amphetamine-Regulated Transcript (CART) gene, are a fascinating class of neuropeptides with a profound influence on fundamental biological processes.CART Peptides These peptides are widely distributed throughout the central nervous system (CNS) and play critical roles in regulating appetite, body weight, reward pathways, and even stress responses. Their discovery has shed light on complex neurobiological mechanisms, offering potential avenues for understanding and treating conditions ranging from obesity to addiction.
The CART gene (CARTPT) encodes a precursor protein that is cleaved into various active CART peptides. Among the most studied are CART(55-102) and CART(62-102)CART. These peptides act as neurotransmitters and co-transmitters within the brain, particularly in regions associated with reward and motivation.CART peptides as modulators of dopamine and ... - PubMed Their unique structure, showing no significant homology to other known peptides, highlights their distinct functional roles.CARTs, kurz für cocaine and amphetamine-regulated transcripts, sind Neuropeptide, die unter anderem eine Rolle bei der Appetitregulation, ... Research indicates that CART peptides can modulate dopamine signaling, a key neurotransmitter in the brain's reward circuitry, thus influencing behaviors related to pleasure, motivation, and reinforcement.
One of the most extensively researched functions of CART peptides is their involvement in appetite control and energy homeostasis. They are recognized as satiety factors, signaling to the brain that food intake should cease. This anorectic effect is crucial for maintaining a healthy body weight. Studies have demonstrated that administration of CART peptides can inhibit feeding behavior, suggesting their importance in preventing overeatingCART Peptides and Drugs of Abuse: A Review of Recent .... Their regulation by leptin, a hormone known to influence appetite and metabolism, further underscores their central role in energy balance.Cocaine and Amphetamine Regulated Transcript (CART), brilliantly identified by Douglass and co-workers is ananorectic peptide regulated by leptin.
The name "Cocaine- and Amphetamine-Regulated Transcript" itself hints at the significant involvement of CART peptides in the brain's response to rewarding substances.作者：J Lau·2014·被引用次数：165—CART is a key neurotransmitter and hormoneinvolved in the regulation of diverse biological processes, including food intake, maintenance of body weight, ... These peptides are expressed in areas of the brain that are heavily implicated in drug addiction, such as the reward pathways.作者：SC Yang·2008—Cocaine- and amphetamine-regulated transcript (CART) peptidewas discovered in the treatment of cocaine and amphetamine addiction in rats and received its ... Research suggests that CART peptides can modulate the motivational and locomotor effects of psychostimulants like cocaine and amphetamines.Unique, Specific CART Receptor-Independent Regulatory ... This connection has led to investigations into CART peptides as potential targets for developing novel therapies to combat drug addiction. By influencing reward signaling, CART peptides may play a role in both the development of addiction and the potential for recovery.CART is a neuropeptide encoded by the CARTPT gene in humans. CART seems to play a role in reward, feeding, and stress, and exits the functional properties of ...
The influence of CART peptides extends beyond appetite and reward. Emerging research points to their involvement in other critical physiological and behavioral processes:
* Stress Response: CART peptides have been observed to play a role in the body's response to stress.
* Mood Regulation: There is evidence suggesting a connection between CART peptides and mood, with some studies indicating a role in anxiogenic (anxiety-producing) behavior.
* Antioxidant Properties: Some CART peptides have demonstrated protective effects against oxidative damage, safeguarding cellular components like mitochondrial DNA, proteins, and lipids from harmful reactive oxygen species.
* Learning and Memory: Recent findings suggest that CART peptides may also influence learning and memory processes, particularly in relation to drug-induced behaviors.
* Gastrointestinal Motility: Central administration of CART peptides has been shown to alter gastrointestinal motility, indicating a broader influence on the body's systems.作者：P Kristensen·1998·被引用次数：1666—Here we show thatCART(cocaine- and amphetamine-regulated transcript), a brain-located peptide 5,6,7,8 , is a satiety factor and is closely associated with ...
The multifaceted roles of CART peptides in the CNS position them as promising targets for therapeutic interventions作者：MJ Kuhar·1999·被引用次数：214—CART peptides are novel, putative brain–gut neurotransmitters and co-transmittersthat probably have a role in drug abuse, the control of feeding behavior.. Their involvement in appetite regulation suggests potential applications in treating obesity, while their influence on reward pathways offers hope for new strategies in addiction treatmentCART. Furthermore, their potential antioxidant and mood-regulating properties open up avenues for research into other neurological and psychiatric disorders. Continued exploration into the precise mechanisms of CART peptide action, their receptor interactions, and their modulation by various physiological and pharmacological factors will be crucial in unlocking their full therapeutic potential.and Amphetamine-regulated Transcript (CART) Peptide ...
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