Siinfeklpeptide The dominant search intent for "ova peptide sequence" is informational, focusing on understanding specific peptide sequences derived from ovalbumin and their roles, particularly in immunological contexts. The SERP data highlights two primary OVA peptide sequences: OVA (257-264) and OVA (323-339), both recognized for their roles as epitopes presented by MHC molecules.
Tier 1:
* Core Entities: OVA peptide sequence, Ovalbumin (OVA), OVA (257-264), OVA (323-339), SIINFEKL
* High-Relevance Phrases: H-2Kb-restricted OVA class I epitope, class I (Kb)-restricted peptide epitope of OVA, OVA 323-339 peptide, OVA 257-264
* Search Intent Signals: peptide, sequence, ovalbumin peptide
Tier 2:
* Related Entities/Concepts: MHC, T cell activation, epitope, antibody production, carrier protein, chicken ovalbumin, UniProt ID: P01012
* Attributes/Variations: ISQAVHAAHAEINEAGR, H-2Kb, I-A(d), Molecular Weight, Purity, Solubility, trifluoroacetate salt, lyophilized powder
* Related Searches: Ova peptide323 339, Siinfeklpeptide, Ovalbumin, Ovasiinfekl, OT-II peptide, OVA protein, Ova official website
Tier 3:
* Chinese characters and highly specific chemical identifiers that don't directly add to the general understanding of the OVA peptide sequenceOVA Peptide (257-264) | 138831-86-4 | POV-3659-PI.
* Highly commercial terms like "MedchemExpress.com", "CAS", and "EBSCO" unless discussing their specific product offerings in detail.
* Repetitive mentions of "peptide" without specific context.
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The OVA peptide sequence refers to specific fragments derived from ovalbumin, a major protein found in egg white.OVA (257-264) (H-2Kb) | 1 mg | EP01994_1 These peptides are of significant interest in immunology and biomedical research due to their roles as epitopes, particularly in antigen presentation and T cell activation. The most commonly studied OVA peptide sequences are OVA (257-264) and OVA (323-339), each recognized for its unique interaction with the Major Histocompatibility Complex (MHC) and its subsequent presentation to T cells.
Ovalbumin (OVA) is a large protein, but specific regions within its amino acid chain can act as critical signaling units for the immune system. Research has identified several key peptide sequences, with two standing out for their extensive use in experimental models:
* OVA (257-264) Peptide: This is a well-characterized class I (Kb)-restricted peptide epitope of OVA.Five distinct regions were found to contain dominant allergic IgE epitopes, these being L38T49,. D95A102, E191V200, V243E248 and G251N260.Ovalbumin(OVA) is widely used in allergy research.OVA peptide323-339 has been reported to be responsible for 25–. It is an octameric peptide, meaning it consists of eight amino acids. Its sequence is commonly referred to as SIINFEKLThey cover a broad range of different MHC alleles and come with a tailored MHCpeptide-loading protocol, enabling fast and convenient TCR and epitope screening.. This peptide is crucial for activating CD8+ T cells, which are a vital component of the adaptive immune response, particularly in cell-mediated immunity.This is a class I (Kb)-restrictedpeptideepitope ofOVA, an octamericpeptidefromovalbuminpresented by the class I MHC molecule, H-2Kb.Ovalbumin peptideSIINFEKL (H-2 Kb) for stimulation of T cells. Singlepeptide(SIINFEKL) for stimulation of mouse. The H-2Kb molecule, a specific MHC class I allele found in mice, is responsible for presenting the SIINFEKL peptide to CD8+ T cells. This interaction is fundamental in studying immune responses to viral infections and cancer, as well as in the development of cancer immunotherapies.
* OVA (323-339) Peptide: This sequence is a longer peptide, encompassing amino acids 323 to 339 of ovalbumin.Sequence (Three Letter Code),Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu; Calculated Molecular Weight, 963.2 ; Molecular Formula, C45H74N10O13 ; Form, Lyophilized powder. Its full sequence is ISQAVHAAHAEINEAGR. This peptide is recognized as an I-A(d)-restricted OVA class II epitope. MHC class II molecules, such as I-A(d), typically present peptides to CD4+ T cells, which play a central role in orchestrating immune responses, including helping B cells produce antibodies and activating cytotoxic T cellsOVA (323 - 339) peptide sequenceis H - Ile - Ser - Gln - Ala - Val - His - Ala - Ala - His - Ala - Glu - Ile - Asn - Glu - Ala - Gly - Arg – OH, An H-2b- .... The OVA (323-339) peptide is widely used in research to study T helper cell responses and to investigate mechanisms of immune tolerance and allergy.
The defined nature and immunogenicity of these OVA peptide sequences make them invaluable tools in immunological research.
* Antigen Presentation Studies: Researchers utilize these peptides to investigate the intricate processes of antigen presentation, where fragments of antigens are displayed on the surface of cells by MHC molecules. Understanding how ovalbumin peptide fragments are processed and presented helps elucidate immune recognition mechanisms.
* T Cell Activation and Elicitation: Both OVA (257-264) and OVA (323-339) are employed to stimulate specific T cell populations in vitro and in vivo. This allows scientists to study T cell function, cytokine production, and the development of immune memoryOVA 323-339 Peptide (ISQAVHAAHAEINEAGR) - CAS. For instance, the OVA (257-264) peptide is frequently used in assays to assess CD8+ T cell responses, while OVA (323-339) is used to study CD4+ T cell responsesOVA 257-264is used to stimulate T cells in PBMCs and to quantify peptide epitope specificity and IFN-γ releasing effector cells by ELISPOT assay. OVA 257-264 ....
* Allergy and Tolerance Research: Ovalbumin itself is a common allergen, and studying its derived peptides, particularly OVA (323-339), contributes to understanding the mechanisms behind food allergies and developing strategies for immune tolerance.MACSpep Ova | Miltenyi Biotec | Hong Kong
* Vaccine Development and Cancer Immunotherapy: The ability of these peptides to elicit robust immune responses makes them candidates for inclusion in experimental vaccines. In cancer research, understanding how tumor antigens like OVA peptides are presented can inform the design of immunotherapies aimed at enhancing the body's ability to fight cancer cellsOVA Peptide (257-264) | 138831-86-4 | POV-3659-PI.
When working with OVA peptide sequences, several properties are important:
* Purity and Synthesis: These peptides are typically synthesized chemically to ensure high purity, often exceeding 95%. They are usually supplied as lyophilized powders, which require reconstitution for experimental use.
* Molecular Weight and Formula: Each peptide sequence has a specific molecular weight and chemical formula, which are crucial for accurate experimental calculations and identification.
* Epitope Mapping: Beyond the two primary sequences, research has also identified other regions on the ovalbumin protein that can serve as epitopes, such as aa 243-248 and aa 127-136, contributing to a broader understanding of the immune response to OVA.The principle of delivery of T cell epitopes to antigen ...
In summary, the OVA peptide sequence, particularly the well-defined fragments OVA (257-264) and OVA (323-339), serves as a cornerstone in immunological research. Their predictable interaction with MHC molecules and ability to elicit specific T cell responses make them indispensable tools for dissecting cellular immunity, developing novel therapeutic strategies, and advancing our understanding of immune system function.
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